Treatment-Resistant Depression / Bipolar Clinic

The London Psychiatry Centre / Services / Treatment-Resistant Depression / Bipolar Clinic

Find the ‘you’ that’s been hiding in the highs and lows

A different approach to bipolar spectrum disorders, with years of proven success

When you have been struggling with your mental health for a long time, it can feel like you are running in circles. You may have tried different therapies, various medications and countless doctors, yet the stability and success you deserve still feels out of reach.

We believe that recovery shouldn’t be a moving target. Our specialists are here to help restore your wellbeing in a safe, discreet environment.

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Why Our Approach To Bipolar Spectrum Disorders Is Different

Why our approach to bipolar spectrum disorders is different

If you have found that previous treatments have had little-to-no effect on your wellbeing, you aren’t alone. For many of our patients, misdiagnosis, ineffective treatment, or adverse side effects from medication have inhibited recovery.

At The London Psychiatry Centre, we go further to support your recovery, combining world-leading expertise with our patented, non-invasive treatment programme for bipolar disorder. Our goal is to provide you with a precise diagnosis and a treatment plan tailored to your needs, so that you can feel like yourself again.

Why our approach to bipolar spectrum disorders is different

If you have found that previous treatments have had little-to-no effect on your wellbeing, you aren’t alone. For many of our patients, misdiagnosis, ineffective treatment, or adverse side effects from medication have inhibited recovery.

At The London Psychiatry Centre, we go further to support your recovery, combining world-leading expertise with our patented, non-invasive treatment programme for bipolar disorder. Our goal is to provide you with a precise diagnosis and a treatment plan tailored to your needs, so that you can feel like yourself again.

The Zamar Protocol ®

The Zamar Protocol ® is a concierge service for treatment-resistant depression or bipolar disorder

Our centre is the only centre in the world with the expertise and ability to offer it. 96.4% of our patients experience a sustained recovery, typically after years of unsuccessful treatment.

Our patented*, evidence-based treatment, The Zamar Protocol ® (Precision guided high-dose thyroid hormones and rTMS protocol) is the most effective treatment for resistant depression, even when ECT fails, as 80% of these are subthreshold bipolar.

Precision diagnoses

By looking beyond superficial assessments and carefully analysing the data unique to you, we can reach a definitive diagnosis. This precision often provides the answers that previous evaluations may have missed.

Groundbreaking treatment

The Zamar Protocol ® (Precision guided high-dose thyroid hormones and rTMS protocol), developed by Dr Andy Zamar, is an exclusive, patented treatment designed to restore balance to the brain’s regulatory systems.

Prioritising your quality of life

Our pain-free, antidepressant free treatment for bipolar is personalised to you, and centred on improving your quality of life.

The Zamar Protocol ® (Precision guided high-dose thyroid hormones and rTMS protocol) is currently offered on a case-by-case basis.

Gold-standard recognition

Our evidence-based results feature in The Maudsley Prescribing Guidelines, the essential evidence-based handbook on psychiatric prescribing worldwide.

*Patents granted: United States (patent no. 11,638,831), Europe (patent no. 3723805), and the UK (application no. EP18822464.6).

More than a million people live with bipolar in the UK, and it takes an average of 9.5 years to receive a diagnosis after first seeking help.

- Bipolar UK Report 2024/25

52%

or more

of people with treatment-resistant depression in the U.K. actually have undiagnosed subthreshold bipolar disorder

Is it treatment-resistant depression, or something else?

Many of our patients come to us having been diagnosed with Treatment-Resistant Depression(TRD). However, we often find that the issue isn’t a lack of effort or a “hand-to-treat” condition; it’s that the root cause hasn’t been fully understood.

The line between depression and bipolar spectrum disorders is often thinner than people think. In fact, research shows that over half of those diagnosed with depression in the UK may actually be experiencing subthreshold bipolar disorder. This means that there is s specific reason why traditional treatments haven’t worked (or have made symptoms worse), and a distinct path to finally feeling better.

Bipolar disorder treatment results in numbers

Our bipolar disorder treatment results have been described as “life-changing” by our patients and noted for their excellence by the Care Quality Commission (CQC).

Traditional treatment The London Psychiatry Centre
41.8% remission rate 96.4% remission rate
Significant side effects Minimal to no side effects
Limited success with rapid cycling bipolar Proven success across all bipolar types

Is our bipolar disorder treatment, The Zamar Protocol ®, right for you?

Our bipolar clinic is designed for anyone who feels they haven’t yet found the answer to their mood fluctuations.

Whether you are seeking a first-time assessment, have felt “stuck” in your current treatment for years, or suspect your existing diagnosis of treatment-resistant depression may be incorrect, we are here to provide support and answers.

The Zamar Protocol ® (Precision guided high-dose thyroid hormones and rTMS protocol) is currently offered on a case-by-case basis.

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Is Our Bipolar Disorder Treatment Right For You?

Is our bipolar disorder treatment, The Zamar Protocol ®, right for you?

Our bipolar clinic is designed for anyone who feels they haven’t yet found the answer to their mood fluctuations.

Whether you are seeking a first-time assessment, have felt “stuck” in your current treatment for years, or suspect your existing diagnosis of treatment-resistant depression may be incorrect, we are here to provide support and answers.

The Zamar Protocol ® (Precision guided high-dose thyroid hormones and rTMS protocol) is currently offered on a case-by-case basis.

Book Online

This man will be enough to save me because he understands.

'After the appointment, I said to Mum: 'This man will be enough to save me because he understands.' There were no deliberations, waitlists, or delays and I started a combined treatment... with immediate effect.'

— Review for Dr Andy Zamar. Read the full review here.

Frequently asked questions

about treatment for bipolar disorders

+ - How do I know if I have bipolar disorder or just depression?

The symptoms of these two conditions can overlap, which is why misdiagnosis is so common. If you find that your “lows” are sometimes accompanied by periods of high energy, racing thoughts, increased irritability, or if standard antidepressants haven’t helped you feel better, it is worth a specialist assessment. We look for “subthreshold” signs that other screenings may miss.

+ - What is bipolar disorder?

Bipolar disorder is a serious mental illness responsible for mood swings from extreme highs to extreme lows. Bipolar disorder is an illness which has a severe impact on quality of life. It carries a high depression burden, considerable suicide rate (18%), an early death by 10 years from heart disease in 4/10, and has a very severe impact on relationships. But our bipolar clinic is here to help you get your life back.

A World Health Organisation (WHO) study found that over a lifetime, the level of disability in bipolar spectrum disorder is greater than all forms of cancer, epilepsy, and all known neurological diseases, including Alzheimer’s disease.

+ - What are the different types of bipolar?

The Zamar Protocol ® (Precision guided high-dose thyroid hormones and rTMS protocol) can be used to treat all types of bipolar disorder. There are three common types: bipolar type I, bipolar type II, and subthreshold bipolar disorder.

Bipolar type I, the classic type, is characterised by a minimum of 7 days of mania and 2 weeks of depression. Those with bipolar type I have had at least one period of mania in their life.

Bipolar type II is characterised by minimum periods of 2 weeks of depression and 4 days of hypomania, a lesser form of elevated mood without periods of full-blown mania.

Subthreshold bipolar disorder or unspecified bipolar disorder is the most common form of bipolar disorder and occurs in 55-60% of all bipolar disorder cases. It will present with symptoms of mania, depression and mixed states but will not meet the duration criteria of 7 days/2 weeks of Bipolar I and 4 days/2 weeks of bipolar II disorders. Symptoms can last as little as minutes to 3 days.

Read more about the types of bipolar disorder.

+ - What is The Zamar Protocol ® (Precision guided high-dose thyroid hormones and rTMS protocol)?

This is a patented, non-invasive treatment that involves a combination of precision medicine, high-dose thyroid hormones, and non-invasive treatment rTMS (Repetitive Transcranial Magnetic Stimulation). It is exceptionally safe and is designed to have minimal to no side effects. It is now featured in The Maudsley Prescribing Guidelines, the gold standard for safe psychiatric prescribing worldwide. It is available exclusively at The London Psychiatry Centre. Read our recently published articles on our patented treatment here: https://www.mdpi.com/1861888 and https://www.mdpi.com/1832476. Find out more about our treatment programme here.

+ - I’ve tried medication before. Why would this be different?

Other treatments focus on managing symptoms with medications such as antidepressants, which may come with unwanted side effects. Our approach uses precision medicine to target the biological root of mood instability. Because we reach a more precise diagnosis through data-led investigations, we can prescribe and administer treatments that actually align with your needs.

+ - Do I need a GP referral to book an appointment?

No, you do not need a referral from your GP to see one of our consultants. You can book a private, confidential consultation directly with our team. We are here to provide a discreet and supportive environment from your very first call.

+ - How long does the treatment take to show results?

While every patient is unique, many of our patients report feeling a significant difference much sooner than with traditional medication alone. Our high remission rate of 96.4% is a testament to the efficiency of The Zamar Protocol ® (Precision guided high-dose thyroid hormones and rTMS protocol) in restoring balance.

020 7580 4224 info@psychiatrycentre.co.uk Book appointment