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Medical Doctors Educational Area

The London Psychiatry Centre / Medical Doctors Educational Area

Here you will find a series of educational resources for GPs.

High-Dose Thyroid Hormones Educational Area

Please find below the evidence base for high-dose thyroid hormones and their effectiveness in treating Rapid Cycling Bipolar Disorder (RPCBP).

If you have any further queries, please do get in touch with us at the centre and we would be happy to answer your questions.

The Maudsley Prescribing Guidelines in Psychiatry 14th Edition

David M. Taylor, Thomas R. E. Barnes, Allan H. Young.
For information on the prescribing of levothyroxine see page 285.

Adjunctive thyroid hormone treatment in rapid cycling bipolar disorder: A double-blind placebo-controlled trial of levothyroxine (L-T4) and triiodothyronine (T3).

Patricia D Walshaw, Laszlo Gyulai, Michael Bauer, Mark S Bauer, Brian Calimlim, Catherine A Sugar, Peter C Whybrow. Bipolar Disorders: An International Journal of Psychiatry And Neurosciences, 2018.

Efficacy of quetiapine monotherapy in rapid-cycling bipolar disorder in comparison with sodium valproate.

Jens M Langosch, Tobias Drieling, Nane C Biedermann, Christoph Born, Johanna Sasse, Hartmut Bauer, Joerg Walden,  Michael Bauer, Heinz Grunze. Journal of Clinical Psychopharmacology, 2008.

Treatment-resistant depression: experience of the first repetitive transcranial magnetic stimulation clinic in the UK.

Rafael Euba, Irina Panihhidina, Andy Zamar. Future Medicine, 2015.

Handbook of diagnosis and treatment of bipolar disorders.

Edited by Terence A. Ketter, M.D.
Chapter: Management of acute Major Depressive Episodes in Bipolar Disorder. Page 217.

High-dose levothyroxine for the management of bipolar affective disorder: two case reports.

Andy Zamar, Gurvinder Warrya, Christos Kouimtsidis. Journal of the Royal Society of Medicine, 2017.

The failure to know what isn’t known: negative publication bias with lamotrigine and a glimpse inside peer review.

S. N. Ghaemi. British Medical Journal, 2009.

Quetiapine monotherapy in bipolar II depression: combined data from four large, randomized studies.

Allan H Young, Joseph R Calabrese, Urban Gustafsson, Michael Berk, Susan L McElroy, Michael E Thase, Trisha Suppes and Willie Earley. International Journal of Bipolar Disorders, 2013.

High-dose Levothyroxine for bipolar disorder; the potential role of thyroid function and genetic tests. Report from twenty cases.

Andy Zamar, Robin Roberts, Alexander Bedu-Addo, Abbi Lulsegged and Christos Kouimtsidis. International Journal of Psychiatry Research, 2021.

Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone.

Andrew A Nierenberg, Michael J Ostacher, Joseph R Calabrese, Terence A Ketter, Lauren B Marangell, David J Miklowitz, Sachiko Miyahara, Mark S Bauer, Michael E Thase, Stephen R Wisniewski, Gary S Sachs. American Journal of Psychiatry, 2006.

Treatment of bipolar depression with supraphysiologic doses of levothyroxine: a randomized, placebo-controlled study of comorbid anxiety symptoms.

Maximilian Pilhatsch, Thomas J Stamm, Petra Stahl, Ute Lewitzka, Anne Berghöfer, Cathrin Sauer, Michael Gitlin, Mark A. Frye, Peter C. Whybrow & Michael Bauer. International Journal of Bipolar Disorders, 2019.

Treatment of rapid-cycling bipolar disorder: are antidepressants mood destabilizers?

S. Nassir Ghaemi. American Journal of Psychiatry, 2008.

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